SETTER (RNA SEcondary sTructure-based TERtiary structure similarity) represents a tool for pairwise comparison of RNA 3D structures. To do so, SETTER employs secondary structure information, i.e., formations created in sequence of nucleic acids formed by hydrogen bonds. With the help of secondary structure information, a 3D superposition is carried out. It follows from the structure-function correlation assumption that by findind similar 3D structures, SETTER can predict function of an unknown RNA structure. Such an prediction can be done by inspecting the 3D superopositions of similar structures provided by SETTER.
|Participants||Daniel Svozil, David Hoksza, Petr Čech|